SNRIs on the NCLEX
Venlafaxine, duloxetine: dual reuptake inhibitors. Uses, side effects, BP monitoring.
SNRIs inhibit both serotonin and norepinephrine reuptake. Used for depression, anxiety, neuropathic pain.
Common drugs
Venlafaxine (Effexor), duloxetine (Cymbalta), desvenlafaxine.
Uses
Depression. Generalized anxiety. Neuropathic pain (duloxetine especially). Fibromyalgia.
Side effects
Similar to SSRIs (GI, sexual, headache). Hypertension at higher doses (especially venlafaxine), monitor BP.
Discontinuation
Venlafaxine has prominent discontinuation syndrome. Taper slowly.
Frequently asked
Which SNRI for neuropathic pain?
Duloxetine is FDA-approved for diabetic neuropathy and fibromyalgia.
Same MAOI washout as SSRIs?
Yes, 2 weeks both directions.
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